Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 3-7 h [1]
  Clearance: The total body clearance of drug is 0.10-0.77 L/min [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 15 - 142 days [1]
  Metabolism: The drug is metabolized via the CYP3A4 and CYP2C8 enzymes [2]
  Vd: The volume of distribution (Vd) of drug is 9.26-17.17 L/kg [3]

References

• [1] FDA Approved Drug Products: CORDARONE (amiodarone HCl) tablets
• [2] Lu D, Xie Q, Wu B: N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. J Pharm Biomed Anal. 2017 Oct 25;145:692-703. doi: 10.1016/j.jpba.2017.07.037. Epub 2017 Aug 4.
• [3] Riva E, Gerna M, Latini R, Giani P, Volpi A, Maggioni A: Pharmacokinetics of amiodarone in man. J Cardiovasc Pharmacol. 1982 Mar-Apr;4(2):264-9. doi: 10.1097/00005344-198203000-00015.